4.10's in the city improve mpg, i got 1-2 more mpg in the city, you can select a higher gear to drop the rpms sooner really. like cruising at 30 i can shift into 4th instead of keeping it in 3rd, dropping the rpm lower in some cases.
4.10's on the highway will decrease mpg more, i dropped from 28 to 25.
still i run at 2.3kish rpm at 65 IIRC (i haven't driven the stang for a few months

) which isn't bad. If i did it again, i would buy 4.10's without thinking about it.
with a supercharger... idk, never driven a stang with 4.10s and S/C.